According to IRIB World Service, the anti-US demonstrations were held in the Qatif region of Eastern Province, the cities of Omran, Dammam and several other areas late on Saturday.
The protesters chanted slogans against the United States and set its flags on fire.
The demonstrators also called on the Saudi regime to expel the US ambassador and recall the Saudi envoy from Washington.
They said Washington was responsible for the production of the sacrilegious movie, demanding that the perpetrators of such insults be brought to justice.
